NFL DFS Sunday Night Football picks: Broncos vs. 49ers SNF Fantasy lineup advice for DraftKings, FanDuel

The Week 3 NFL schedule features a Sunday Night Football matchup between Russell Wilson and the Denver Broncos and Jimmy Garoppolo and the San Francisco 49ers. The host Broncos are looking to build off a sloppy 16-9 win over the Houston Texans, while the 49ers are coming off a 27-7 blowout win over the Seattle Seahawks. Wilson owns a 17-4 record in 21 starts against the 49ers, but this will be his first as a member of the Broncos. Are Wilson and Garoppolo must-start options in your Sunday Night Football Showdown NFL DFS strategy? Or would it make sense to build your NFL DFS Showdown lineups around a star wide receiver, running back, tight end, or D/ST? Deebo Samuel, George Kittle, Courtland Sutton, Javonte Williams, and Jerry Jeudy could all be impact NFL DFS picks in your 49ers vs. Broncos DFS strategy on Sunday night.

Before making any NFL DFS Sunday picks for Broncos vs. 49ers on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor. 

Kaylor is an NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

In the Broncos vs. Seahawks Week 1 Monday Night Football matchup, Kaylor listed Denver wide receiver Jerry Jeudy as one of his top Showdown DFS picks. The result: Jeudy hauled in four passes for 102 yards and a touchdown and was the highest scoring fantasy player in the game.

In the Week 2 Monday night double-header, Kaylor called for a huge night from Buffalo wide receiver Stefon Diggs. The two-time Pro Bowler would go on to catch 12 passes for 148 yards and three touchdowns and was the highest scoring player DFS player on the slate.

In the Browns-Steelers Week 3 Thursday Night Football matchup, Kaylor was all over running back Nick Chubb and wide receiver Amari Cooper. Both players went off, scoring well over 20 DFS points each. 

Now, Kaylor has turned his attention to Broncos vs. 49ers on Sunday Night Football Week 3 and locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Broncos vs. 49ers on SNF

One player Kaylor will be definitely be backing in his 49ers vs. Broncos SNF DFS picks is San Francisco tight end George Kittle. The 28-year-old tight end will be making his 2022 NFL season debut after missing two games with a groin injury. Kittle faces a Denver defense on Sunday Night Football that has had issues defending elite tight ends for years and will be without All-Pro safety Justin Simmons. With Garoppolo stepping back in as the 49ers’ starting quarterback, Kaylor is projecting Kittle to be a DFS Showdown must-start.

“Denver has struggled against elite tight ends and with Justin Simmons on IR, I expect that to continue on Sunday night. The best comparison in my eyes is Chiefs tight end Travis Kelce, and he has owned the Broncos in recent years. Add in Jimmy Garoppolo as the 49ers starting quarterback and you have the makings of a huge fantasy night for Kittle in his first action of the season.” You can see the rest of Kaylor’s NFL DFS picks here.

How to make NFL DFS lineups for 49ers vs. Broncos on SNF

Kaylor is also targeting another undervalued option that could explode for huge numbers for Sunday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor’s SNF DFS picks, at SportsLine. 

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Sunday Night Football? And which under-the-radar DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament in 2022, and find out.