Liverpool vs. Southampton prediction, odds, line: Expert reveals 2022 English Premier League picks for May 17

St. Mary’s Stadium hosts a pivotal English Premier League matchup on Tuesday afternoon. Liverpool takes on Southampton in a marquee battle with big-time significance. Liverpool is alive in pursuit of an EPL title, and must win to keep that dream alive. Southampton is safe from relegation and aiming to play spoiler.

Kickoff is scheduled for 2:45 p.m. ET. Caesars Sportsbook lists Liverpool as the -265 favorite (risk $265 to win $100) in its latest Liverpool vs. Southampton odds. Southampton is a +650 underdog, a draw is priced at +420, and the over-under for total goals scored is set at 3.5. Before making any Southampton vs. Liverpool picks, you need to see what proven soccer insider Jon Eimer has to say. 

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, Eimer has covered the English Premier League, Serie A, the FA Cup and much more. The Indiana-based handicapper is on an astounding 43-16 roll on his soccer picks for SportsLine, returning over $1,700 for $100 bettors during that span. He’s also on a 14-7-1 EPL roll, returning over $600 on those picks. 

Now, Eimer has broken down Liverpool vs. Southampton from every angle and just revealed his picks and Premier League predictions. You can head to SportsLine now to see Eimer’s picks. Here are the betting lines and trends for Southampton vs. Liverpool:

• Southampton vs. Liverpool spread: Liverpool -1.5 (-105)
• Southampton vs. Liverpool over-under: 3.5 goals
• Southampton vs. Liverpool money line: Liverpool -265, Draw +420, Southampton +650
• SOU: Southampton is winless in its last four league games
• LIV: Liverpool has won eight of its last nine EPL matches against Southampton

Why you should back Southampton

Southampton has the benefits of playing at home on Tuesday. Southampton defeated Liverpool 1-0 at St. Mary’s last season, and the club has a penchant for playing well in key spots. Southampton also has the rest advantage, with 10 days off against a Liverpool side that had a high-profile match against Chelsea over the weekend. 

Liverpool is also facing injury uncertainty with Virgil van Dijk and Mohamed Salah expected to miss this clash. In addition, Southampton’s talent is better than its record. Southampton is near the middle of the EPL table in expected goal differential, signaling the potential for positive regression. Southampton is also above-average in shots on target percentage on offense.

Why you should back Liverpool

Liverpool already has a domestic double with designs on more. The Reds are No. 2 in the EPL table with 86 points, and Liverpool has only two losses in 36 EPL matches and one loss in any competition in 2022. Liverpool is tremendous on offense, scoring 89 goals in EPL play and leading the EPL with 1.89 assists per 90 minutes and 67 total assists. Liverpool is also tied for the best clean sheet percentage (58.3 percent), with a top-three mark in save percentage. 

Liverpool has allowed only 31 goals and a league-leading 16 assists, giving up 0.64 goals and 0.44 assists per 90 minutes. That overall effectiveness led to an FA Cup win for the first time in 16 years, and Liverpool has three of the top seven goal scorers in the English Premier League. Liverpool also has the top two players in assists, and it has been a nightmare season for Southampton with only one victory in the last 11 league matches.

How to make Liverpool vs. Southampton picks

Eimer has scrutinized Southampton vs. Liverpool from every angle, and he is leaning over on the Liverpool team total (2.5). He also provides three other confident best bets, including a pair that return plus money. He’s only sharing his expert EPL picks at SportsLine.

So who wins Southampton vs. Liverpool? And where does all the betting value lie? Visit SportsLine now to see the best bets for Liverpool vs. Southampton, all from the soccer expert who has crushed his picks, and find out.