49ers vs. Eagles prediction, odds, line, start time: 2023 NFL picks, Week 13 best bets from proven model

The Philadelphia Eagles own the NFL’s best record and look to strengthen their lead in the race for the No. 1 overall seed in the NFC as they host the NFC West leading San Francisco 49ers. The Eagles (10-1) defeated the Bills, 37-34 in an overtime thriller on Sunday, while the 49ers (8-3) beat the Seahawks, 31-13 on Thanksgiving night. The teams most recently played in last January’s NFC Championship Game, a 31-7 Philadelphia victory. The Eagles are 7-2-2 against the spread, while the 49ers are 6-5 ATS in 2023.

Kickoff from Lincoln Financial Field is set for 4:25 p.m. ET. San Francisco is a 3-point road favorite in the latest 49ers vs. Eagles odds via SportsLine consensus, while the over/under is 48. Before making any Eagles vs. 49ers picks of your own, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2023 NFL season on an incredible 175-126 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 29-18 roll on top-rated NFL picks since Week 7 of last season and is 22-8 straight-up the last two weeks.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Niners vs. Eagles and just locked in its picks and NFL Week 13 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Eagles vs. Niners:

• Eagles vs. 49ers spread: 49ers -3
• Eagles vs. 49ers over/under: 48 points
• Eagles vs. 49ers money line: 49ers -157, Eagles +133
• Eagles vs. 49ers picks: See picks at SportsLine
• Eagles vs. 49ers live stream: fubo (try for free)

Why the 49ers can cover

In the three games since their bye week, San Francisco has looked absolutely dominant, winning by 31, 13 and 18 points. Star running back Christian McCaffrey leads the NFL in rushing/receiving touchdowns with 16, after a two touchdown performance against Seattle. In the Thanksgiving night game, McCaffrey rushed 19 times for 114 yards and caught five passes for 25 yards. If he remains healthy, teams likely won’t have an answer to slow him down in this potent offense.

Quarterback Brock Purdy has been excellent since the 49ers’ three game midseason losing streak. Against the Seahawks, he didn’t have to do the heavy lifting, throwing for only 209 yards and a touchdown on 21 of 30 passing with one interception. Purdy was injured early in last year’s NFC Championship Game loss and seemingly wants a bit of revenge against the team who denied San Francisco a spot in last year’s Super Bowl. See which team to pick here.

Why the Eagles can cover

Philadelphia has been playing with fire of late, having won each of its last four games by one possession. In Sunday’s dramatic overtime victory over Buffalo, Jalen Hurts solidified himself atop the current MVP leaders by throwing for 200 yards and three touchdowns and rushing for two more. On the season, Hurts has thrown for 18 scores and rushed for 11 more, most of which have come via the rugby-style play known affectionately as “The Brotherly Shove.”

After a six game stretch with 125 or more receiving yards, star Philadelphia wide receiver A.J. Brown has been quiet of late, combining for only 111 yards and two touchdowns over the last three games. With tight end Dallas Goedert out the last two weeks, the Eagles No. 2 receiver, Devonta Smith, has lines of 6-99-0 and 7-106-1 after posting only two 99+ yard performances in the season’s first nine games. Against a stout 49ers defense, the Eagles will need to be crisp on offense and Hurts will likely need to target Brown and Smith early and often. See which team to pick here.

How to make 49ers vs. Eagles picks

The model has simulated San Francisco vs. Philadelphia 10,000 times and the results are in. It is leaning Under on the point total, and it also says one side of the spread hits more than 50% of the time. You can only see the model’s Eagles vs. 49ers pick at SportsLine.

So who wins Philadelphia vs. San Francisco on Sunday, and which side of the spread hits more than 50% of the time? Visit SportsLine right now to see which side of the Eagles vs. 49ers spread you should be all over Sunday, all from the model on a 175-126 roll on its top-rated NFL picks, and find out.