2024 college football Week 4 picks against the spread, odds, lines, trends: Vegas expert reveals picks

New conference matchups will be in the spotlight during the Week 4 college football schedule. No. 11 USC travels to No. 18 Michigan in a Big Ten showdown between opponents that met eight times in the Rose Bowl. The latest Week 4 college football odds via SportsLine consensus list the Trojans as 6-point favorites. In the SEC, No. 6 Tennessee will look to stay hot against No. 15 Oklahoma (+7) as the Sooners play the first conference matchup as an SEC squad.

Other Week 4 college football lines of note include No. 16 LSU (-23) against UCLA, No. 12 Utah (+2.5) against No. 14 Oklahoma State and No. 21 Clemson (-17) against NC State. Before locking in any Week 4 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce’s vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects.

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 4 and revealed picks for each matchup. Head here to see every pick.

Top college football predictions for Week 4

One of the top college football picks Marshall is recommending for Week 4: He’s backing No. 15 Oklahoma to stay within the 7-point spread against No. 6 Tennessee on Saturday at 7:30 p.m. ET in Norman. 

The Vols have rolled to a 3-0 start with three comfortable covers. Oklahoma, however, should be extremely fired up for its first ever conference matchup in the SEC. The Sooners are also taking on Tennessee head coach Josh Heupel, a national-championship winning quarterback at OU in 2000.

Marshall notes that Oklahoma coach Brent Venables is on a 7-2 run against the spread in Norman dating back to last season. Tennessee, meanwhile, covered just once on the road last season. Marshall is also on the Over (57.5) since the Vols have cleared the total in all three games this season and OU is coming on an Over in Week 3. See which other picks to make here. 

How to make college football picks for Week 4

Marshall has evaluated every other matchup and he’s found an alarming 11-0 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about in one of the week’s biggest games? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 4 college football odds 

See full Week 4 college football picks, odds, predictions here

Thursday, Sept. 19

South Alabama at Appalachian State (-7, 62.5)

Friday, Sept. 20

Stanford at Syracuse (-9.5, 57)

Illinois at Nebraska (-9, 43.5)

San Jose State at Washington State (-14, 55)

Saturday, Sept. 21

North Carolina State at Clemson (-17, 48)

Florida at Mississippi State (+4.5, 58.5)

Marshall at Ohio State (-39.5, 51)

Arkansas at Auburn (-4, 58)

USC at Michigan (+5.5, 46.5)

Utah at Oklahoma State (-2.5, 52)

Tennessee at Oklahoma (+7, 57.5)

Louisiana-Monroe at Texas (-45, 53)

Baylor at Colorado (-1, 54)

Kansas State at BYU (+7, 47.5)