Mike Tyson vs. Jake Paul odds, prediction, props, date, rules: Nov. 15 fight card picks from boxing expert

Mike Tyson has a career boxing record of 50-6, winning via knockout 44 times over his legendary career. When Tyson was squaring off against lifelong boxers like Frank Bruno, Donovan Ruddock and Evander Holyfield, he may have never imagined one day squaring off against someone who became famous as an entertainer. When Mike Tyson vs. Jake Paul takes place on Friday, November 15 from AT&T Stadium, Tyson will be in for a fight. 

The latest Jake Paul vs. Mike Tyson odds from FanDuel list Paul as the -310 favorite (risk $310 to win $100) to win, with Tyson a +240 underdog, with the over/under for total rounds at 5.5, while the fight to go the distance is +176. Paul to win by knockout is +100, while Tyson to win by knockout is +320. The broadcast starts at 8 p.m. ET. Before making any Mike Tyson vs. Jake Paul picks, make sure you see the boxing predictions and betting advice from SportsLine combat expert Brandon Wise.  

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing and mixed martial arts analyst who has consistently provided winning selections for SportsLine members. For the past four years, he has hit numerous boxing selections in big-time matchups.

For example, in March, Wise called a win in Round 1 for Paul (+200) against Ryan Bourland and also advised SportsLine members to take the Under 1.5 rounds (+120). Both bets connected when Paul scored a knockout towards the end of the first round. Anyone who has followed Wise’s combat sports picks has already seen massive returns.

Now, with the Paul vs. Tyson fight card approaching, Wise has studied the matchup from every angle and released confident picks for the fight. You can only see his picks and analysis at SportsLine. 

Mike Tyson vs. Jake Paul predictions  

Wise has analyzed the Jake Paul vs. Mike Tyson bout and is leaning Over 5.5 rounds at -150 odds. Tyson is decades removed from showcasing the right hand that would knock out the best of the best in a matter of seconds, so although he’s looked strong in workout videos posted online, don’t expect Tyson to be packing the same punch he did in the 80s and 90s. Also, the heavier 14-ounce gloves soften the blow of punches, which lowers the chance of a knockout.

These heavier gloves weren’t only done for safety reasons but for entertainment. With the fight having the chance to be the most streamed sporting event around the globe in history, no one involved wants this to be a short event. The 14-ounce gloves help increase the chances of a longer fight and Paul has continued into the sixth round in six of his last eight fights. See who to pick here. 

How to make Jake Paul vs. Mike Tyson picks

Wise has also locked in a confident money line pick and a method-of-victory prop bet that could pay out big. He’s only sharing his picks and analysis at SportsLine.

Who wins Mike Tyson vs. Jake Paul on November 15, and which Paul vs. Tyson props should you be all over? Visit SportsLine now to see Brandon Wise’s best bets for the July 20 bout, all from the CBS combat sports specialist who just called Paul’s first-round win in March, and find out.