NFL football pool, pick’em, office pool, confidence picks: Choose the 49ers in Week 4, 2023

Two AFC East rivals will collide in Week 4 when the Buffalo Bills host the Miami Dolphins on Sunday. The Bills have dominated the series in recent years, winning nine of the last 10 meetings against Miami. However, the Dolphins just dropped 70 points in last week’s victory over the Broncos. Should your Week 4 NFL office pool picks include backing the Bills at home, or will the Dolphins remain undefeated with another victory?

Elsewhere on the Week 4 NFL schedule, Lamar Jackson and the Baltimore Ravens travel to play Myles Garrett and the Cleveland Browns. Will Jackson lead his team to victory on the road and for your NFL confidence pool picks or will the Browns beat their division-rivals? Before you make your NFL predictions, you need to see the Week 4 NFL football pool picks from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2023 NFL season on an incredible 167-117 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 21-9 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up. 

Now, the model has simulated the entire Week 4 NFL schedule 10,000 times and generated its optimal NFL pick’em plays. Head to SportsLine to see them now.

Top Week 4 NFL office pool predictions

One of the top Week 4 NFL predictions from the model: The San Francisco 49ers (-14) comfortably beat the Arizona Cardinals at home. Arizona has struggled mightily against divisional opponents recently, losing six of their last seven games against NFC West foes. The 49ers, meanwhile, have won eight straight against NFC West opponents and are 8-0 against the spread in their last eight games at home.

The 49ers feature one of the league’s most potent rushing attacks behind superstar Christian McCaffrey. San Francisco is averaging 162.7 rushing yards per game and McCaffrey has already racked up 353 rushing yards and three rushing touchdowns through the first three games of the season. SportsLine’s model expects San Francisco’s rushing attack to finish with over 140 rushing yards against the Cardinals, helping the 49ers win outright in over 80% of simulations. See the rest of the model’s Week 4 NFL pool picks here.

How to make Week 4 NFL office pool picks

The model also made the call on every other Week 4 NFL game and has strong picks for potentially close matchups like Bills vs. Dolphins, Ravens vs. Browns, and Bengals vs. Titans. It’s also calling for several favorites to struggle big-time. You can only see all of the model’s NFL pool picks here.

So who should you pick in every Week 4 NFL game, and which favorites should you avoid? Visit SportsLine now to get optimal NFL office pool picks, all from a proven computer model that has returned over $7,000 since its inception, and find out.