Rams vs. 49ers betting guide, 2024 Thursday Night Football odds: AI, model, expert, props, DFS fantasy picks

Brock Purdy and the San Francisco 49ers will host Matthew Stafford and the Los Angeles Rams on Thursday Night Football. Kickoff from Levi’s Stadium is at 8:15 p.m. ET. These two NFC West rivals squared off on Sept. 22, with Los Angeles recording a 27-24 victory. According to the latest Rams vs. 49ers odds, San Francisco is a three-point favorite, while the over/under for total points scored is 49. The 49ers are -150 money line favorites (risk $150 to win $100), while the Rams are +126 underdogs. If you are looking for NFL picks, AI predictions or NFL DFS picks for 49ers vs. Rams, SportsLine has you covered with its proven model, AI PickBot and team of experts. They even have one pick that returns a whopping +8000, so be sure to see what they have to say.

Advanced NFL model simulates Rams vs. 49ers 10,000 times 

SportsLine’s model enters Week 15 of the 2024 NFL season on an incredible 25-11 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 205-139 roll on top-rated NFL picks that dates back to the 2017 season and a 59-32 roll on top-rated NFL picks since Week 7 of 2022. The model has revealed its best bets for 49ers vs. Rams and is backing the Over to hit. You can find the model’s picks on the spread and money line here.

Self-learning AI reveals top player props 

SportsLine AI hit a whopping 2,073 4.5- and 5-star sports betting picks since the start of last season. Now it has locked in its top player props for players like Brock Purdy, Matthew Stafford, Cooper Kupp and George Kittle. One of its top picks is Stafford staying Under 33.5 passing attempts, which has earned a 4-star rating. The AI PickBot is calling for 30 passing attempts on TNF. You can see all the top-rated NFL prop picks from the AI PickBot here.

NFL Vegas expert picks revealed for TNF 

SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. NFL expert Micah Roberts, who is on a blistering 26-6 roll on 49ers games, has analyzed this rivalry from every angle and locked in his best bet for TNF right here.

Eric Cohen, who is 109-51 since Week 4, has revealed his exact score prediction for Rams vs. 49ers, which returns a whopping +8000. That pick, along with his prediction for the other 15 games, is available here. SportsLine’s advanced computer model has also locked in its exact score predictions for 49ers vs. Rams, and every Week 15 NFL game right here.

NFL DFS picks from top experts 

SportsLine has a DFS optimizer that simulates every game 10,000 times and uses info from the SportsLine Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on sites like FanDuel and DraftKings. Their NFL DFS Optimizer has Rams wide receiver Puka Nacua as its top overall player to include in your TNF DFS picks. Here are its complete Rams vs. 49ers NFL DFS rankings. 

DFS Professional Millionaire Mike McClure has locked in his top NFL DFS picks for Rams vs. 49ers on Thursday Night Football. He’s building his NFL DFS lineups around 49ers quarterback Brock Purdy. McClure is also targeting another undervalued player who could explode for huge numbers on TNF. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, right here.

Where to bet on Thursday Night Football

Here are several sportsbooks to bet on NFL games this week, along with the various NFL sportsbook promos they currently offer.