Orioles vs. Twins odds, line, prediction, start time: 2025 MLB picks, May 8 best bets from proven model

Teams trending in opposite directions meet when the Baltimore Orioles battle the Minnesota Twins on Thursday. Minnesota earned a 9-1 win on Tuesday and followed that up with a 5-2 victory on Wednesday. The Orioles (13-22), who have lost four in a row, are 5-13 on the road this season. The Twins (17-20), who have won four straight, are 11-6 on their home field in 2025.

First pitch from Target Field in Minneapolis is set for 1:10 p.m. ET. Minnesota is a -148 favorite on the money line (risk $148 to win $100) in the latest Orioles vs. Twins odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 8.5. Before making any Twins vs. Orioles picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 7 of the 2025 MLB season on a 10-5 run (67%) on top-rated MLB money-line betting picks. Anybody following at sportsbooks and on betting apps could have seen strong returns. 

Now, the model has set its sights on Orioles vs. Twins and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Orioles vs. Twins:

• Orioles vs. Twins money line: Baltimore +124, Minnesota -148 at DraftKings Sportsbook
• Orioles vs. Twins over-under: 8.5 runs  
• Orioles vs. Twins run line: Minnesota -1.5 (+140)
• BAL: The under is 6-3-1 over the past 10 Orioles games  
• MIN: The under is 7-3 over the past 10 Twins games     
• Orioles vs. Twins picks: See picks at SportsLine
• Orioles vs. Twins streaming: FuboTV (Try for free)

Why the Twins can cover

Minnesota is expected to send right-hander Joe Ryan (2-2, 2.93 ERA) to the mound. He is coming off a no-decision in a 6-1 loss at Boston on Friday. In that game, he pitched six innings, allowing four hits, one earned run, one walk and eight strikeouts. In a 5-0 win over the Los Angeles Angels on April 27, he earned the victory and pitched seven innings, allowing four hits and one walk, while striking out 11. In 40 innings pitched this season, Ryan has allowed just 31 hits, 13 earned runs and five walks, while striking out 47.

Center fielder Byron Buxton has been red hot of late, with hits in seven consecutive games, including five multi-hit performances during that stretch. He has also homered in three straight games. In Wednesday’s win over the Orioles, he was 2-for-4 with a homer and three RBI. In 36 career games against Baltimore, he is hitting .258 with 13 doubles, one triple, six homers and 26 RBI. See which team to back at SportsLine.

Why the Orioles can cover

Baltimore is expected to counter with right-handed pitcher Dean Kremer (3-4, 5.73 ERA). He is coming off a solid outing in a 3-0 win over the Kansas City Royals on Friday. In that game, he pitched seven innings, allowing just three hits and one walk, while striking out two. In a 9-1 win over the Cleveland Guardians on April 16, he pitched 5.1 innings, allowing four hits, one earned run and one walk, while fanning two.

Shortstop Gunnar Henderson has hits in 10 of the past 11 games. In Saturday’s 4-0 loss to the Royals, he was 3-for-4. He added two hits, including a double, in an 11-6 loss to the Royals on Sunday. In 28 games this season, he is hitting .252 with seven doubles, one triple, three homers and five RBI. In 12 career games against Minnesota, he is hitting .256 with three homers and eight RBI. See which team to back at SportsLine. 

How to make Orioles vs. Twins picks

SportsLine’s model is leaning Over on the total, projecting 9.5 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Twins vs. Orioles, and which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.