NFL picks this week, Vegas odds, bets: Week 16, 2024 expert predictions against the spread, parlay, plus props

The Cincinnati Bengals will try to continue climbing toward the .500 mark when they host the Cleveland Browns on Sunday during the Week 16 NFL schedule. Cincinnati is coming off back-to-back road wins, but still needs to win its final three games to have a shot at making the NFL playoff bracket. Joe Burrow, Ja’Marr Chase, and the Bengals are 9.5-point favorites in the Week 16 NFL betting lines. Other teams desperately needing victories on Sunday include the Falcons (7-7), Cardinals (7-7) and Colts (6-8). Meanwhile, there are several games with playoff seeding implications on Sunday, as the Commanders (9-5) will host the Eagles (12-2) and the Seahawks (8-6) face the Vikings (12-2).  

Dallas is a 4-point home underdog against Tampa Bay on Sunday Night Football in the latest Week 16 NFL odds, with the Buccaneers trying to extend their four-game winning streak. The Week 16 slate concludes with a Monday Night Football showdown between the Packers (-14, 42) and Saints in a game featuring one of the largest NFL spreads of the entire season. Before locking in any Week 16 NFL picks or NFL prop bets, be sure to check out the Week 16 NFL best bets and predictions from SportsLine’s red-hot Vegas experts. 

SportsLine has more than 40 hand-picked Vegas experts who excel in multiple spots. The NFL, however, is a strength for the site as SportsLine currently has five total experts who are on NFL runs that have returned $1,400 or more for $100 players and one who has returned more than $2,100. Anybody following has seen huge returns. 

Now, with the Week 16 NFL schedule quickly approaching, SportsLine’s top NFL experts are already locking in their picks. Go to SportsLine to see them all now. 

Top Week 16 NFL expert picks from Jason La Canfora

La Canfora has been covering the NFL since 2004 and spent 10 years as CBS’s NFL Insider for “THE NFL TODAY” and across all platforms. He continues to cover the NFL as an analyst and insider for The Washington Post and gather information from a plethora of sources throughout the game. La Canfora is 28-22-1 in his last 51 NFL sides and has already locked in picks for multiple games throughout the weekend. 

One team that La Canfora is high on is Cincinnati, which is a 9.5-point favorite against Cleveland in a game with an over/under of 46.5. The Bengals won the first meeting between these teams by a touchdown and all of their wins have come by at least seven points this season. They have covered the spread in seven of their last 10 home games against the Browns, and they are on a 15-6 ATS run overall in the rivalry. La Canfora is also high on a heavy favorite in a game where he expects the line to move even more. See all of La Canfora’s picks here. 

Top Week 16 expert NFL picks from Daniel Vithlani

Vithlani is a New York-based analyst who brings a dynamic approach to his handicapping and is specializes in the NFL. He is coming off a 27-15 debut season with SportsLine (plus $1,181 for $100 players, every bet 1 unit). Danny also netted 24.8 units during the 2022 NFL season, posting every pick on Instagram. He is 55-34 in his last 89 NFL prop picks, returning nearly $2,000 for $100 bettors.  

Vithlani has released his best bet for Rams (-3, 47) vs. Jets on Sunday. New York snapped a four-game losing streak with a 32-25 win at Jacksonville last week, but it has already been eliminated from the playoff picture. Los Angeles is riding a three-game winning streak as it heads on the road for the second week in a row. Vithlani expects the line to move before kickoff, so he suggests getting ahead of the line movement now. You can see Vithlani’s pick for that game and others here. 

Top Week 16 NFL expert picks from Sia Nejad

Nejad is a trial attorney turned analyst who specializes in the PGA, NFL and college basketball. He further specializes in the DFS and prop market. Nejad is coming off a highly successful NFL season in which he went 79-59-3 (plus $936 for $100 players, every bet 1 unit) at SportsLine. He is 50-31-1 (+1490) in his last 82 NFL picks. 

Nejad has already locked in his pick for the Rams (-3, 47) vs. Jets on Sunday as well. This is the first meeting between these teams since 2020, when the Jets notched a 23-20 road win. It is also a showdown between two of the oldest quarterbacks in the NFL, featuring Aaron Rodgers (41) and Matthew Stafford (36). Nejad is backing the same team as Vithlani, making it a must-see bet. See all of Nejad’s picks here. 

Top Week 16 NFL expert picks from Mike Tierney

Tierney has covered the NFL for decades and reported from seven Super Bowls. He is 154-124-9 in the NFL the past two seasons, returning $1,586 to $100 players (every bet one unit). Tierney enters Week 16 on a 49-25-3 run in his last 68 NFL ATS bets (+2135), making him the hottest expert on the site. 

The veteran sportswriter has already placed his bet on the Bears (+7, 47.5) to cover against the Lions on Sunday. Tierney notes that Detroit will be without multiple starters, which could cause the line to drop before kickoff. He also points out that Chicago has lost three straight division games by a combined seven points, so he expects the Bears to play well in their first home game in a month. You can find all of Tierney’s picks here.

How to make Week 16 NFL against the spread picks

SportsLine’s team of experts also includes R.J. White, who is CBS Sports’ managing editor of Fantasy and gambling. He has cashed huge in the Westgate Las Vegas SuperContest on two occasions, and he went 636-534-34 on ATS picks over the last six years. This week, he’s locked in a bet on a low over/under between teams coming off wins. You can find out who his NFL picks are this weekend here. 

If you are looking for NFL picks, NFL props, or NFL best bets for Week 16, SportsLine has you covered with its proven team of experts. Visit SportsLine now to see who which teams you should back in Week 16, all from a staff that includes five experts who are on NFL runs that have returned $1,400 or more for $100 players.