College football odds, picks, predictions for Week 3, 2024: Proven model backs Ole Miss in best bets

No. 14 Kansas State trailed Tulane for most of the game last week, but the Wildcats came up with a big play defensively to stay unbeaten and add excitement to their matchup against No. 20 Arizona on Friday during the Week 3 college football schedule. Arizona is coming off wins over New Mexico and Northern Arizona, but it is a 7-point underdog against Kansas State in the Week 3 college football odds. That game is one of two ranked vs. ranked matchups in Week 3, with the other one featuring No. 6 Missouri (-16.5) vs. No. 24 Boston College on Saturday afternoon. Missouri has outscored its first two opponents by a combined score of 89-0 as it continues its four-game homestand. 

Meanwhile, some of the top-ranked teams in the country will try to stay unbeaten when they go on the road in Week 3. No. 4 Alabama travels to Wisconsin as a 15.5-point favorite, and No. 1 Georgia is a 24-point favorite at Kentucky in the Week 3 college football lines. Before locking in any Week 3 college football picks, be sure to see the latest college football predictions from SportsLine’s proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns!

Now, it has turned its attention to the latest college football odds and Week 3 college football betting lines on the spread, money line, and over/under. Head here to see every pick.

Top college football predictions for Week 3 

One of the college football picks the model is high on during Week 3: Washington (-4) covers in its rivalry game at Washington State in a 3:30 p.m. ET matchup on Saturday. The Apple Cup generally takes place the Friday after Thanksgiving to close the regular season, but the state’s premier rivalry game was moved to Week 3 this year after Washington left for the Big Ten. The Huskies have dominate this series in recent years, winning nine of the last 10 head-to-head meetings. 

Their program is playing under a new coaching staff, but that has not slowed down the momentum they built during their run to the national championship last year. Washington opened the season with a 35-3 win over Weber State before cruising to a 30-9 win over Eastern Michigan last week. Mississippi State transfer quarterback Will Rogers has thrown for 511 yards and five touchdowns through the first two weeks of the season, and he is a big reason why the model has Washington covering the spread in well over 60% of simulations. See the rest of its Week 3 college football picks here. 

Another prediction: No. 5 Ole Miss (-23.5) covers the huge spread at Wake Forest in a 6:30 p.m. ET kickoff on Saturday. The Rebels have one of the best offenses in college football, and they have outscored their first two opponents by a combined score of 128-3. Senior quarterback Jaxson Dart’s Heisman Trophy campaign is well underway, throwing for 795 yards, six touchdowns and zero interceptions, despite getting to rest down the stretch of both games. 

The Rebels also have an elite rushing attack headlined by senior running back Henry Parrish Jr., who has rushed for 205 yards and four touchdowns on 22 carries. Wake Forest gave up 31 points in a loss to Virginia at home last week, allowing 14 fourth-quarter points after entering the final period with a 30-17 lead. Ole Miss has covered the spread in five of its last six games against ACC opponents, and the model has the Rebels covering almost 60% of the time. See picks for every other game in Week 3 here. 

How to make college football picks for Week 3

The model has also made the call on who wins and covers in every FBS matchup in Week 3, and it’s calling for an underdog to win outright in a primetime game. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdog wins outright in one of the biggest games in Week 3? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.

College football odds for Week 3

See full Week 3 college football picks, odds, predictions here

Thursday, Sept. 12

Arizona State at Texas State (+2, 58.5)

Friday, Sept. 13

UNLV at Kansas (-7, 56.5)

Arizona at Kansas State (-7, 56.5)

Saturday, Sept. 14

LSU at South Carolina (+7, 52)

Alabama at Wisconsin (+15.5, 51)

Boston College at Missouri (-16.5, 54)

Texas A&M at Florida (+3.5, 47)

Tulane at Oklahoma (-13.5, 50.5)

Oregon at Oregon State (+14, 50)

Washington State at Washington (-4, 55)

Notre Dame at Purdue (+12.5, 45.5)

Georgia at Kentucky (+24, 45)

Colorado at Colorado State (+7.5, 59.5)

Indiana at UCLA (+2.5, 47.5)