2024 Week 10 NFL picks, odds, best bets from advanced model: This 5-way football parlay pays 25-1

The New York Jets were able to keep their realistic playoff hopes alive when they beat the Texans last Thursday, but they have no wiggle room heading into their matchup against the Cardinals on Sunday during the Week 10 NFL schedule. They are 1-point road underdogs in the Week 10 NFL odds, as Arizona tries to extend its three-game winning streak. The Cardinals are coming off one of their best performances of the season, cruising to a 29-9 win over Chicago. Should you target either side of that matchup with your Week 10 NFL bets?

There are only four other Week 10 NFL spreads that are three points or smaller, while five teams are favored by more than six points in the NFL betting lines. Which Week 10 NFL lines off the most value for your Week 10 NFL parlay picks? Before you make any Week 10 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2024 NFL season on an incredible 14-7 sports betting hot streak on top-rated NFL picks this year. Longer term, it is on a 195-136 roll on top-rated NFL picks that dates back to the 2017 season and a 49-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has scoured the Week 10 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 10 NFL picks at SportsLine.

Top Week 10 NFL picks

After simulating every game 10,000 times, the model is high on the Chicago Bears (-6.5, 39.5) to cover at home against the New England Patriots. Chicago enters this game on a two-game losing streak, but it is still alive in the NFL playoff hunt with a 4-4 record. The Bears have won their first three home games of the season, with all three of those wins coming by at least six points. 

Rookie quarterback Caleb Williams threw four interceptions in his first three games, but he only has one interception in his five games since then. He is facing a New England team that has lost seven of its last eight games and has turned the ball over 11 times. The Patriots are already out of the playoff conversation, which is one reason why the model has the Bears covering the spread in almost 60% of simulations. See which other NFL parlay picks to make here.

How to make Week 10 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright, defying oddsmakers everywhere. You can only see the model’s Week 10 NFL best bets and parlay at SportsLine.

What are the model’s top Week 10 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 10 NFL best bets from a model on an 195-136 run on top-rated picks, and find out.