Cowboys vs. 49ers odds, prediction, spread, line: Sunday Night Football picks from NFL model on 12-5 roll

The Dallas Cowboys (3-3) and the San Francisco 49ers (3-4) are set to link up in a primetime battle on Sunday Night Football. The 49ers are coming off a 28-18 loss to the Kansas City Chiefs, while the Cowboys had a much-needed bye in Week 7 that came after Dallas was embarrassed at home by the Detroit Lions, 47-9. Micah Parsons (ankle) is out for the Cowboys. Receivers Deebo Samuel (illness) and Jauan Jennings (knee) are questionable for San Francisco.

Kickoff from Levi’s Stadium in San Francisco is set for 8:20 p.m. ET. San Francisco is a 4-point favorite in the latest Cowboys vs. 49ers odds from the SportsLine Consensus, while the over/under for total points scored is 47. The 49ers are -207 money-line favorites (risk $207 to win $100), while the Cowboys are +172 underdogs (risk $100 to win $172). Before locking in any Cowboys vs. 49ers picks, make sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2024 NFL season on an incredible 12-5 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 193-134 roll on top-rated NFL picks that dates back to the 2017 season and a 47-27 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has simulated Cowboys vs. 49ers 10,000 times and just revealed its coveted NFL picks and Week 8 betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and NFL betting lines for Cowboys vs. 49ers:

• Cowboys vs. 49ers spread: San Francisco -4
• Cowboys vs. 49ers over/under: 47 points
• Cowboys vs. 49ers money line: San Francisco -207, Dallas +172
• DAL: Cowboys have hit the 1H money-line in seven of their last 10 away games
• SF: 49ers have hit the Team Total Under in eight of their last 11 games at home
• Cowboys vs. 49ers picks: See picks at SportsLine
• Cowboys vs. 49ers streaming: FuboTV (Try for free)

Why the 49ers can cover

The 49ers have been hit with injuries to the offensive side of the ball. Despite that, quarterback Brock Purdy has been upright. The Iowa State product is currently third in the league in passing yards (1,841), but 11th in passing touchdowns (nine) and QBR (60.9). He has thrown for 200-plus yards in every game this season.

In the backfield, running back Jordan Mason has been a productive force. He’s tough to bring down in open space and picks up yards after contact. The 25-year-old ranks second in the NFL in carries (128) and rushing yards (667) with three touchdowns. He has finished with at least 50 rushing yards in seven straight games. See who to back at SportsLine.

Why the Cowboys can cover

Quarterback Dak Prescott has the accuracy to layer throws on all three levels while being able to diagnose coverages quickly. The 31-year-old is 10th in the NFL in passing yards (1,602) with eight touchdowns.

Receiver CeeDee Lamb regularly showcases why he’s one of the best playmakers in the game. Lamb lines up all over the formation with sticky hands. The Oklahoma product can also be shifty in open space. This season, he has 32 receptions for 467 yards and two touchdowns. Lamb has notched 80-plus yards in three games this season. In his last outing, he had seven catches for 89 yards. See who to back at SportsLine.

How to make Cowboys vs. 49ers picks

SportsLine’s model is leaning Over on the point total, projecting the teams to combine for 52 points. The model also says one side of the spread has all the value. You can head to SportsLine to see the model’s picks. 

So who wins 49ers vs. Cowboys on Sunday Night Football, and which side of the spread has all the value? Visit SportsLine now to see which side of the 49ers vs. Cowboys spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.