Monday Night Football prediction, odds, time, spread, line: Chiefs vs. Saints picks from expert on 23-11 run

The two-time defending Super Bowl champion Kansas City Chiefs look for their fifth win in a row to start the season when they take on the New Orleans Saints on Monday Night Football. Kansas City is off to its best start since 2020, when it started off 4-0 and was 14-1 after Week 16. The Saints (2-2), who were 3-2 against AFC foes a year ago, are 1-1 on grass fields since the start of 2023. The Chiefs (4-0), who are 1-0 against the NFC South this season, are 9-6 on grass surfaces since last September.

The game is slated to start at 8:15 p.m. ET at GEHA Field at Arrowhead Stadium in Kansas City, Mo. The Saints have the ninth-best offense in the NFL so far this year, averaging 349 yards per game, while the Chiefs are 14th at 328.3. After opening at -7.5, Kansas City is now favored by 5.5 points in the latest Chiefs vs. Saints odds via SportsLine consensus, while the over/under for total points scored is 43. Before making any Saints vs. Chiefs picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Danny Vithlani, considering his mastery of picks involving the NFL.

Vithlani is coming off a 27-15 debut season on NFL picks with SportsLine, and in 2024 Vithlani has gone 23-11 on his last 34 NFL picks, returning $1,086. Anyone who has followed him is way up.

Now, Vithlani has locked in on Chiefs vs. Saints and just revealed his coveted NFL picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on the spread, money line and over/under for Saints vs. Chiefs:

• Chiefs vs. Saints spread: Kansas City -5.5
• Chiefs vs. Saints over/under: 43 points
• Chiefs vs. Saints money line: Kansas City -248, New Orleans +202
• NO: The Saints have hit the first-half Over in nine of their last 11 away games (+6.70 units)
• KC: The Chiefs have hit the fourth-quarter Under in 17 of their last 19 games (+14.75 units)
• Chiefs vs. Saints picks: See picks at SportsLine
• Chiefs vs. Saints streaming: FuboTV (Try for free)

Why the Chiefs can cover

Quarterback Patrick Mahomes completed 19 of 29 attempts (65.5%) for 245 yards and a touchdown with one interception last week. He is one of two quarterbacks (Geno Smith) with a 65-plus completion percentage and a touchdown pass in each of his first four weeks of the season. Mahomes has a 100-plus rating in two of the past three games at home. He passed for 254 yards and three touchdowns with no interceptions with a 92 rating in the last meeting with the Saints. He has dominated on Monday Night Football, compiling a 6-2 mark with 23 touchdowns (21 passing, two rushing) with six interceptions and a 99.3 rating in eight career starts.

Running back Kareem Hunt totaled 85 yards from scrimmage (69 rushing, 16 receiving) in his season debut last week. He also has played well on Monday Night Football. In six career games on MNF, he has 657 scrimmage yards (109.5 per game) and four TDs (two rushing, two receiving). The eighth-year veteran has played in 92 career games, rushing for 4,505 yards and 40 touchdowns. He also has 228 receptions for 1,906 yards and 17 touchdowns. See who to back at SportsLine.

Why the Saints can cover

Quarterback Derek Carr has been solid so far this season. In four games, he has completed 72 of 100 passes for 824 yards and six touchdowns with three interceptions and a rating of 103.9. He has also carried eight times for 22 yards (2.8 average) and one touchdown. In Sunday’s loss at Atlanta, he completed 28 of 36 passes (77.8%) for 239 yards and one interception.

Powering the New Orleans rushing attack is running back Alvin Kamara. The eighth-year veteran has carried 80 times for 362 yards (4.5 average) and five touchdowns this season. He also has 17 receptions for 174 yards (10.2 average) and one TD. In 105 career games, he has rushed for 6,191 yards and 59 touchdowns. See who to back at SportsLine.

How to make Chiefs vs. Saints picks

Vithlani has analyzed Saints vs. Chiefs from every possible angle. He’s leaning Under the total and has also discovered a critical X-factor that has him jumping all over one side of the spread. Find out what it is, and which team to back, at SportsLine. 

So who wins Saints vs. Chiefs on Monday Night Football, and what critical x-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Saints vs. Chiefs spread to back, all from the expert who is 23-11 on NFL picks, and find out.